Publications

Nanoparticle Targeting in Chemo-Resistant Ovarian Cancer Reveals Dual Axis of Therapeutic Vulnerability Involving Cholesterol Uptake and Cell Redox Balance.

Wang Y, Calvert AE, Cardenas H, Rink JS, Nahotko D, Qiang W, Ndukwe CE, Chen F, Keathley R, Zhang Y, Cheng J-X, Thaxton CS, Matei D

Adv Sci (Weinh). 2024 Apr; 11(13): e2305212-. | https://doi.org/10.1002/advs.202305212

PMID: 38263873

Highly sensitive and ultra-rapid antigen-based detection of SARS-CoV-2 using nanomechanical sensor platform.

Agarwal DK, Nandwana V, Henrich SE, Josyula VPVN, Thaxton CS, Qi C, Simons LM, Hultquist JF, Ozer EA, Shekhawat GS, Dravid VP

Biosens Bioelectron. 2022 Jan; 195: 113647-. | https://doi.org/10.1016/j.bios.2021.113647

PMID: 34583103

Spectrum of Apolipoprotein AI and Apolipoprotein AII Proteoforms and Their Associations With Indices of Cardiometabolic Health: The CARDIA Study.

Wilkins JT, Seckler HS, Rink J, Compton PD, Fornelli L, Thaxton CS, LeDuc R, Jacobs D, Doubleday PF, Sniderman A, Lloyd-Jones DM, Kelleher NL

J Am Heart Assoc. 2021 Sep; 10(17): e019890-. | https://doi.org/10.1161/JAHA.120.019890

PMID: 34472376

Synthetic high-density lipoprotein nanoparticles: Good things in small packages.

Lavker RM, Kaplan N, McMahon KM, Calvert AE, Henrich SE, Onay UV, Lu KQ, Peng H, Thaxton CS

Ocul Surf. 2021 Jul; 21: 19-26. | https://doi.org/10.1016/j.jtos.2021.03.001

PMID: 33894397

Targeted reduction of cholesterol uptake in cholesterol-addicted lymphoma cells blocks turnover of oxidized lipids to cause ferroptosis.

Rink JS, Lin AY, McMahon KM, Calvert AE, Yang S, Taxter T, Moreira J, Chadburn A, Behdad A, Karmali R, Thaxton CS, Gordon LI

J Biol Chem. 2021; 296: 100100-. | https://doi.org/10.1074/jbc.RA120.014888

PMID: 33208460

Prostate cancer extracellular vesicles mediate intercellular communication with bone marrow cells and promote metastasis in a cholesterol-dependent manner.

Henrich SE, McMahon KM, Plebanek MP, Calvert AE, Feliciano TJ, Parrish S, Tavora F, Mega A, De Souza A, Carneiro BA, Thaxton CS

J Extracell Vesicles. 2020 Dec; 10(2): e12042-. | https://doi.org/10.1002/jev2.12042

PMID: 33408816 ISSN: 2001-3078

HDL nanoparticles have wound healing and anti-inflammatory properties and can topically deliver miRNAs.

Wang J, Calvert AE, Kaplan N, McMahon KM, Yang W, Lu KQ, Peng H, Thaxton CS, Lavker RM

Adv Ther (Weinh). 2020 Dec; 3(12): | https://doi.org/10.1002/adtp.202000138

PMID: 33709017

Tri-ethylene glycol modified class B and class C CpG conjugated gold nanoparticles for the treatment of lymphoma.

Lin AY, Rink JS, Karmali R, Xu J, Kocherginsky M, Thaxton CS, Gordon LI

Nanomedicine. 2020 Nov; 30: 102290-. | https://doi.org/10.1016/j.nano.2020.102290

PMID: 32798731

Targeted reduction of cholesterol uptake in cholesterol-addicted lymphoma cells blocks turnover of oxidized lipids to cause ferroptosis.

Rink JS, Lin AY, McMahon KM, Calvert AE, Yang S, Taxter T, Moreira J, Chadburn A, Behdad A, Karmali R, Thaxton CS, Gordon LI

J Biol Chem. 2020 Nov; 296: 100100-. |https://doi.org/10.1074/jbc.RA120.014888

PMID: 33410414

Interparticle Molecular Exchange of Surface Chemical Components of Native High-Density Lipoproteins to Complementary Nanoparticle Scaffolds.

McMahon KM, Calvert AE, Dementieva IS, Hussain S, Wilkins JT, Thaxton CS

ACS Sens. 2020 Oct; 5(10): 3019-3024. | https://doi.org/10.1021/acssensors.0c01117

PMID: 32643928

Biomimetic Magnetic Nanostructures: A Theranostic Platform Targeting Lipid Metabolism and Immune Response in Lymphoma.

Singh A, Nandwana V, Rink JS, Ryoo S-R, Chen TH, Allen SD, Scott EA, Gordon LI, Thaxton CS, Dravid VP

ACS Nano. 2019 Sep; 13(9): 10301-10311. | https://doi.org/10.1021/acsnano.9b03727

PMID: 31487458

An update on synthetic high-density lipoprotein-like nanoparticles for cancer therapy.

Henrich SE, Thaxton CS

Expert Rev Anticancer Ther. 2019 Jun; 19(6): 515-528. | https://doi.org/10.1080/14737140.2019.1624529

PMID: 31148521

Supramolecular Assembly of High-Density Lipoprotein Mimetic Nanoparticles Using Lipid-Conjugated Core Scaffolds.

Henrich SE, Hong BJ, Rink JS, Nguyen ST, Thaxton CS

J Am Chem Soc. 2019 Jun; 141(25): 9753-9757. | https://doi.org/10.1021/jacs.9b00651

PMID: 31177775

A Targeted, Differential Top-Down Proteomic Methodology for Comparison of ApoA-I Proteoforms in Individuals with High and Low HDL Efflux Capacity.

Seckler HDS, Fornelli L, Mutharasan RK, Thaxton CS, Fellers R, Daviglus M, Sniderman A, Rader D, Kelleher NL, Lloyd-Jones DM, Compton PD, Wilkins JT

J Proteome Res. 2018 Jun; 17(6): 2156-2164. | https://doi.org/10.1021/acs.jproteome.8b00100

PMID: 29649363

Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells.

Murmann AE, Gao QQ, Putzbach WE, Patel M, Bartom ET, Law CY, Bridgeman B, Chen S, McMahon KM, Thaxton CS, Peter ME

EMBO Rep. 2018 Mar; 19(3): | https://doi.org/10.15252/embr.201745336

PMID: 29440125

Scavenger Receptor Type B1 and Lipoprotein Nanoparticle Inhibit Myeloid-Derived Suppressor Cells.

Plebanek MP, Bhaumik D, Bryce PJ, Thaxton CS

Mol Cancer Ther. 2018 Mar; 17(3): 686-697. | https://doi.org/10.1158/1535-7163.MCT-17-0981

PMID: 29282300

Nitric Oxide-Delivering High-Density Lipoprotein-like Nanoparticles as a Biomimetic Nanotherapy for Vascular Diseases.

Rink JS, Sun W, Misener S, Wang J-J, Zhang ZJ, Kibbe MR, Dravid VP, Venkatraman S, Thaxton CS

ACS Appl Mater Interfaces. 2018 Feb; 10(8): 6904-6916. | https://doi.org/10.1021/acsami.7b18525

PMID: 29385802

HDL nanoparticles targeting sonic hedgehog subtype medulloblastoma.

Bell JB, Rink JS, Eckerdt F, Clymer J, Goldman S, Thaxton CS, Platanias LC

Sci Rep. 2018 Jan; 8(1): 1211-. | https://doi.org/10.1038/s41598-017-18100-8

PMID: 29352211

The Potential of Fluocinolone Acetonide to Mitigate Inflammation and Lipid Accumulation in 2D and 3D Foam Cell Cultures.

Nguyen LTH, Muktabar A, Tang J, Wong YS, Thaxton CS, Venkatraman SS, Ng KW

Biomed Res Int. 2018; 2018: 3739251-. | https://doi.org/10.1155/2018/3739251

PMID: 30596089

Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche.

Plebanek MP, Angeloni NL, Vinokour E, Li J, Henkin A, Martinez-Marin D, Filleur S, Bhowmick R, Henkin J, Miller SD, Ifergan I, Lee Y, Osman I, Thaxton CS, Volpert OV

Nat Commun. 2017 Nov; 8(1): 1319-. | https://doi.org/10.1038/s41467-017-01433-3

PMID: 29105655